MolNFT v1 · #67363 · protein

Crystal structure of apo (91-244) ria subunit of camp-dependent protein kinase

3IIA · Camp-dependent protein kinase type I-alpha regulatory…: “Crystal structure of apo (91-244) ria subunit of camp-dependent protein kinase”. X-ray diffraction, 2 pockets (best druggability 0.38). MolNFT v1 #67363 on GenesisL1: 3D…

PDB: 3IIA
Type: protein
Length: 137 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Camp-dependent protein kinase type I-alpha regulatory subunit
UniProt: P00514
Pockets: 2 · best druggability 0.38

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Camp-dependent protein kinase type I-alpha regulatory subunit	protein	137	30% helix, 26% strand	P00514

Ligands and binding sites

GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	61	0.38	0.79	14	GOL
2	53	0.30	0.76	17	empty

Compared structures

3IIA · Crystal structure of apo (91-244) RIa subunit of cAMP-dependent protein kinase · the same entry in another collection · chain A against A, TM-score 1.00
P00514 · AlphaFold monomer V2.0 prediction for camp-dependent protein kinase type I-alpha… · a predicted model of the same protein · chain A against A, TM-score 0.74

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00514
Elsewhere: RCSB PDB 3IIA · PDBe 3IIA · UniProt P00514

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