MolNFT v1 · #66809 · protein
Gamma-subunit of the translation initiation factor 2 from S. solfataricus in complex with GPP(CH2)P
3I1F · Translation initiation factor 2 subunit gamma: “Gamma-subunit of the translation initiation factor 2 from S. solfataricus in complex with GPP(CH2)P”. X-ray diffraction, 2 ligands (GCP, PO4), 14 pockets (best druggability 0.77).…
- PDB
- 3I1F
- Type
- protein
- Length
- 828 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Translation initiation factor 2 subunit gamma
- UniProt
- Q980A5
- Ligands
- GCP, PO4
- Pockets
- 14 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 11% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Translation initiation factor 2 subunit gamma | protein | 414 | 11% helix, 31% strand | Q980A5 |
Ligands and binding sites
- GCP · Phosphomethylphosphonic acid guanylate ester · ligand · 2 copies · chains A, B
- PO4 · Phosphate ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 983 | 0.77 | 0.79 | 110 | GCP, PO4 |
| 2 | 77 | 0.73 | 0.96 | 25 | empty |
| 3 | 385 | 0.63 | 0.78 | 37 | empty |
| 4 | 353 | 0.62 | 0.78 | 38 | empty |
| 5 | 414 | 0.61 | 0.76 | 50 | empty |
Interfaces
1 interface between chains.
- A–B · 784 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 3I1F · Gamma-subunit of the translation initiation factor 2 from S. solfataricus in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- Q980A5 · AlphaFold monomer V2.0 prediction for translation initiation factor 2 subunit gamma… · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q980A5
- Elsewhere: RCSB PDB 3I1F · PDBe 3I1F · UniProt Q980A5
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