MolNFT v1 · #66781 · protein

Structure of the S. pombe NBS1 FHA/BRCT-repeat domain

3I0M · DNA repair and telomere maintenance protein NBS1: “Structure of the S. pombe NBS1 FHA/BRCT-repeat domain”. X-ray diffraction, 2 pockets (best druggability 0.33). MolNFT v1 #66781 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 3I0M
Type: protein
Length: 319 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA repair and telomere maintenance protein NBS1
UniProt: O43070
Pockets: 2 · best druggability 0.33

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA repair and telomere maintenance protein NBS1	protein	319	30% helix, 23% strand	O43070

Ligands and binding sites

GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	55	0.33	0.77	15	empty
2	53	0.29	0.76	18	empty

Modifications

Observed in the structure: 8 modified (engineered).

Compared structures

3I0M · Structure of the S. pombe Nbs1 FHA/BRCT-repeat domain · the same entry in another collection · chain A against A, TM-score 1.00
O43070 · AlphaFold monomer V2.0 prediction for DNA repair and telomere maintenance protein NBS1… · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O43070
Elsewhere: RCSB PDB 3I0M · PDBe 3I0M · UniProt O43070

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