MolNFT v1 · #66673 · protein
Crystal structure of schistosome EIF4E complexed with M7GPPPG and 4E-bp
3HXI · Eukaryotic translation initiation 4E: “Crystal structure of schistosome EIF4E complexed with M7GPPPG and 4E-bp”. X-ray diffraction, 1 ligand (GTG), 1 pocket (best druggability 0.54). MolNFT v1 #66673 on GenesisL1: 3D structure…
- PDB
- 3HXI
- Type
- protein
- Length
- 196 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation 4E; Eukaryotic translation initiation factor 4E…
- UniProt
- Q13541
- Ligands
- GTG
- Pockets
- 1 · best druggability 0.54
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation 4E | protein | 182 | 31% helix, 28% strand | — |
| C | Eukaryotic translation initiation factor 4E- binding protein 1 | protein | 14 | 50% helix, 0% strand | Q13541 |
Ligands and binding sites
- GTG · 7-methyl-guanosine-5'-triphosphate-5'-guanosine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 240 | 0.54 | 0.77 | 26 | GTG |
Interfaces
1 interface between chains.
- A–C · 764 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 3HXI · Crystal structure of Schistosome eIF4E complexed with m7GpppG and 4E-BP · the same entry in another collection · chain A against A, TM-score 1.00
- Q13541 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E-binding… · a predicted model of the same protein · chain C against A, TM-score 0.65
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13541
- Elsewhere: RCSB PDB 3HXI · PDBe 3HXI · UniProt Q13541
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