MolNFT v1 · #66661 · protein
Crystal structure of cralbp mutant R234W
3HX3 · Retinaldehyde-binding protein 1: “Crystal structure of cralbp mutant R234W”. X-ray diffraction, 1 ligand (RET), 6 pockets (best druggability 0.83). MolNFT v1 #66661 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3HX3
- Type
- protein
- Length
- 250 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Retinaldehyde-binding protein 1
- UniProt
- P12271
- Ligands
- RET
- Pockets
- 6 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 56% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Retinaldehyde-binding protein 1 | protein | 250 | 56% helix, 11% strand | P12271 |
Ligands and binding sites
- RET · Retinal · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 205 | 0.83 | 0.96 | 26 | RET |
| 2 | 160 | 0.43 | 0.74 | 20 | empty |
| 3 | 76 | 0.38 | 0.77 | 16 | empty |
| 4 | 61 | 0.33 | 0.77 | 18 | empty |
| 5 | 56 | 0.31 | 0.76 | 17 | empty |
Modifications
Observed in the structure: 5 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12271
- Elsewhere: RCSB PDB 3HX3 · PDBe 3HX3 · UniProt P12271
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