MolNFT v1 · #66570 · protein
Structures of spop-substrate complexes: insights into molecular architectures of btb-CUL3 ubiquitin ligases: SPOPMATHX/BTB/3-box- PUCSBC1
3HU6 · Speckle-type poz protein: “Structures of spop-substrate complexes: insights into molecular architectures of btb-CUL3 ubiquitin ligases…”. X-ray diffraction, 4 pockets (best druggability 0.52). MolNFT v1 #66570 on GenesisL1: 3D…
- PDB
- 3HU6
- Type
- protein
- Length
- 578 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Speckle-type poz protein; Puckered
- EC
- 3.1.3.-, 3.1.3.16, 3.1.3.48
- UniProt
- O43791, Q9VHV8
- Pockets
- 4 · best druggability 0.52
Structure
x-ray diffraction · 3 distinct chains · 35% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Speckle-type poz protein | protein | 284 | 35% helix, 29% strand | O43791 |
| B | Speckle-type poz protein | protein | 282 | 36% helix, 30% strand | O43791 |
| C, D | Puckered (EC 3.1.3.-, 3.1.3.16, 3.1.3.48) | protein | 6 | 0% helix, 17% strand | Q9VHV8 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 202 | 0.52 | 0.77 | 27 | empty |
| 2 | 299 | 0.50 | 0.73 | 32 | empty |
| 3 | 130 | 0.41 | 0.74 | 18 | empty |
| 4 | 74 | 0.33 | 0.75 | 14 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2229 Ų buried · 29 hydrogen bonds · protein-protein
- B–D · 381 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 361 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3HU6 · Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3… · the same entry in another collection · chain A against A, TM-score 1.00
- O43791 · AlphaFold monomer V2.0 prediction for speckle-type poz protein (O43791) · a predicted model of the same protein · chain A against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43791
- Every structure of UniProt Q9VHV8
- Elsewhere: RCSB PDB 3HU6 · PDBe 3HU6 · UniProt O43791 · UniProt Q9VHV8
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