MolNFT v1 · #66415 · protein

Oxidized dimeric PICK1 PDZ C46G mutant in complex with the carboxyl tail peptide of GLUR2

3HPM · Prkca-binding PROTEIN,9-mer peptide of the GLUR2 subunit: “Oxidized dimeric PICK1 PDZ C46G mutant in complex with the carboxyl tail peptide of GLUR2”. X-ray diffraction, 4 pockets (best druggability 0.53). MolNFT v1 #66415 on…

PDB: 3HPM
Type: protein
Length: 219 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Prkca-binding PROTEIN,9-mer peptide of the GLUR2 subunit
UniProt: Q6GQQ2
Pockets: 4 · best druggability 0.53

Structure

x-ray diffraction · 2 distinct chains · 20% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Prkca-binding PROTEIN,9-mer peptide of the GLUR2 subunit	protein	108	20% helix, 33% strand	Q6GQQ2
B	Prkca-binding PROTEIN,9-mer peptide of the GLUR2 subunit	protein	111	20% helix, 32% strand	Q6GQQ2

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	165	0.53	0.79	26	empty
2	185	0.52	0.78	36	empty
3	86	0.42	0.79	18	empty
4	77	0.41	0.79	19	empty

Interfaces

1 interface between chains.

A–B · 885 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

3HPM · Oxidized dimeric PICK1 PDZ C46G mutant in complex with the carboxyl tail peptide of GluR2 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6GQQ2
Elsewhere: RCSB PDB 3HPM · PDBe 3HPM · UniProt Q6GQQ2

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