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Oxidized dimeric PICK1 PDZ C46G mutant in complex with the carboxyl tail peptide of GLUR2

Analyse Oxidized dimeric PICK1 PDZ C46G mutant in complex with the carboxyl tail… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3HPM
Type: protein
Length: 219 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Prkca-binding PROTEIN,9-mer peptide of the GLUR2 subunit
UniProt: Q6GQQ2
Pockets: 4 · best druggability 0.53

Structure

x-ray diffraction · 2 distinct chains · 20% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Prkca-binding PROTEIN,9-mer peptide of the GLUR2 subunit	protein	108	20% helix, 33% strand	Q6GQQ2
B	Prkca-binding PROTEIN,9-mer peptide of the GLUR2 subunit	protein	111	20% helix, 32% strand	Q6GQQ2

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	165	0.53	0.79	26	empty
2	185	0.52	0.78	36	empty
3	86	0.42	0.79	18	empty
4	77	0.41	0.79	19	empty

Interfaces

1 interface between chains.

A–B · 885 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

3HPM · Oxidized dimeric PICK1 PDZ C46G mutant in complex with the carboxyl tail peptide of GluR2 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6GQQ2
Elsewhere: RCSB PDB 3HPM · PDBe 3HPM · UniProt Q6GQQ2

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