MolNFT v1 · #66413 · protein
Oxidized dimeric PICK1 PDZ in complex with the carboxyl tail peptide of GLUR2
3HPK · Prkca-binding PROTEIN,9-mer peptide of the GLUR2 subunit: “Oxidized dimeric PICK1 PDZ in complex with the carboxyl tail peptide of GLUR2”. X-ray diffraction, 1 pocket (best druggability 0.70). MolNFT v1 #66413 on GenesisL1: 3D…
- PDB
- 3HPK
- Type
- protein
- Length
- 219 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Prkca-binding PROTEIN,9-mer peptide of the GLUR2 subunit
- UniProt
- Q6GQQ2
- Pockets
- 1 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 20% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Prkca-binding PROTEIN,9-mer peptide of the GLUR2 subunit | protein | 112 | 20% helix, 36% strand | Q6GQQ2 |
| B | Prkca-binding PROTEIN,9-mer peptide of the GLUR2 subunit | protein | 107 | 20% helix, 35% strand | Q6GQQ2 |
Ligands and binding sites
- GOL · Glycerol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 375 | 0.70 | 0.82 | 48 | empty |
Interfaces
1 interface between chains.
- A–B · 964 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 3HPK · Oxidized dimeric PICK1 PDZ in complex with the carboxyl tail peptide of GluR2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6GQQ2
- Elsewhere: RCSB PDB 3HPK · PDBe 3HPK · UniProt Q6GQQ2
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