Research workbench
Oxidized dimeric PICK1 PDZ in complex with the carboxyl tail peptide of GLUR2
Analyse Oxidized dimeric PICK1 PDZ in complex with the carboxyl tail peptide of GLUR2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3HPK
- Type
- protein
- Length
- 219 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Prkca-binding PROTEIN,9-mer peptide of the GLUR2 subunit
- UniProt
- Q6GQQ2
- Pockets
- 1 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 20% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Prkca-binding PROTEIN,9-mer peptide of the GLUR2 subunit | protein | 112 | 20% helix, 36% strand | Q6GQQ2 |
| B | Prkca-binding PROTEIN,9-mer peptide of the GLUR2 subunit | protein | 107 | 20% helix, 35% strand | Q6GQQ2 |
Ligands and binding sites
- GOL · Glycerol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 375 | 0.70 | 0.82 | 48 | empty |
Interfaces
1 interface between chains.
- A–B · 964 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 3HPK · Oxidized dimeric PICK1 PDZ in complex with the carboxyl tail peptide of GluR2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6GQQ2
- Elsewhere: RCSB PDB 3HPK · PDBe 3HPK · UniProt Q6GQQ2
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