MolNFT v1 · #66394 · protein
Crystal structure of human dck R104M/D133A in complex with L-dt and ADP
3HP1 · Deoxycytidine kinase: “Crystal structure of human dck R104M/D133A in complex with L-dt and ADP”. X-ray diffraction, 2 ligands (ADP, LLT), 2 pockets (best druggability 0.68). MolNFT v1 #66394 on GenesisL1: 3D structure, binding sites…
- PDB
- 3HP1
- Type
- protein
- Length
- 226 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Deoxycytidine kinase
- EC
- 2.7.1.74
- UniProt
- P27707
- Ligands
- ADP, LLT
- Pockets
- 2 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 57% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Deoxycytidine kinase (EC 2.7.1.74) | protein | 226 | 57% helix, 12% strand | P27707 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 224 | 0.68 | 0.85 | 40 | ADP, LLT |
| 2 | 53 | 0.31 | 0.76 | 13 | empty |
Compared structures
- 3HP1 · Crystal structure of human dCK R104M/D133A in complex with L-dT and ADP · the same entry in another collection · chain A against A, TM-score 1.00
- P27707 · AlphaFold monomer V2.0 prediction for deoxycytidine kinase (P27707) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P27707
- Elsewhere: RCSB PDB 3HP1 · PDBe 3HP1 · UniProt P27707
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.