MolNFT v1 · #66304 · protein

Crystal structure of the second bromodomain of human poly-bromodomain containing protein 1 (PB1)

3HMF · Protein polybromo-1: “Crystal structure of the second bromodomain of human poly-bromodomain containing protein 1 (PB1)”. X-ray diffraction, 2 ligands (ZN, CL), 1 pocket (best druggability 0.48). MolNFT v1 #66304 on GenesisL1: 3D…

PDB: 3HMF
Type: protein
Length: 116 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein polybromo-1
UniProt: Q86U86
Ligands: ZN, CL
Pockets: 1 · best druggability 0.48

Structure

x-ray diffraction · 1 distinct chain · 66% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein polybromo-1	protein	116	66% helix, 2% strand	Q86U86

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A
CL · Chloride ion · ion · 2 copies · chains A
EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	91	0.48	0.81	16	empty

Compared structures

3HMF · Crystal Structure of the second Bromodomain of Human Poly-bromodomain containing protein… · the same entry in another collection · chain A against A, TM-score 1.00
Q86U86 · AlphaFold monomer V2.0 prediction for protein polybromo-1 (Q86U86) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q86U86
Elsewhere: RCSB PDB 3HMF · PDBe 3HMF · UniProt Q86U86

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