MolNFT v1 · #6625 · protein

Recombinant human coagulation factor xiii

1FIE: “Recombinant human coagulation factor xiii”. X-ray diffraction, 16 pockets (best druggability 0.83). MolNFT v1 #6625 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1FIE
Type: protein
Length: 1,420 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Coagulation factor xiii
EC: 2.3.2.13
UniProt: P00488
Pockets: 16 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 15% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Coagulation factor xiii (EC 2.3.2.13)	protein	705	15% helix, 41% strand	P00488
B	Coagulation factor xiii (EC 2.3.2.13)	protein	715	15% helix, 41% strand	P00488

Pockets

16 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1144	0.83	0.84	111	empty
2	968	0.83	0.84	99	empty
3	507	0.76	0.84	56	empty
4	134	0.69	0.90	26	empty
5	131	0.64	0.87	30	empty

Interfaces

1 interface between chains.

A–B · 2351 Å² buried · 34 hydrogen bonds · protein-protein

Compared structures

1FIE · Recombinant human coagulation factor xiii · the same entry in another collection · chain A against A, TM-score 1.00
P00488 · AlphaFold monomer V2.0 prediction for coagulation factor xiii a chain (P00488) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00488
Elsewhere: RCSB PDB 1FIE · PDBe 1FIE · UniProt P00488

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