Human carbonic anhydrase II in complex with (2,3,4,6-tetra-O-acetyl- beta-D-galactopyranosyl) -(1-4)-1,2,3,6-tetra-O-acetyl-1-thio-beta-D- glucopyranosylsulfonamide

Structure

x-ray diffraction · 1 distinct chain · 15% helix, 31% strand (DSSP).

Ligands and binding sites

• Z3K · (1S)-2,3,6-tri-O-acetyl-1,5-anhydro-1-sulfamoyl-D-glucitol · ligand · chains A
• Z3L · 2,3,4,6-tetra-O-acetyl-beta-D-galactopyranose · ligand · chains A
• ZN · Zinc ion · metal · chains A
• GOL · Glycerol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 3HKN · Human carbonic anhydrase II in complex with (2,3,4,6-Tetra-O-acetyl-beta-D-galactopyranosy… · the same entry in another collection · chain A against A, TM-score 1.00
• P00918 · AlphaFold monomer V2.0 prediction for carbonic anhydrase 2 (P00918) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P00918
• Elsewhere: RCSB PDB 3HKN · PDBe 3HKN · UniProt P00918