MolNFT v1 · #6623 · protein
Structure of human gamma fibrinogen 30 kd carboxyl terminal fragment
1FIC: “Structure of human gamma fibrinogen 30 kd carboxyl terminal fragment”. X-ray diffraction, 1 ligand (CA), 3 pockets (best druggability 0.70). MolNFT v1 #6623 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1FIC
- Type
- protein
- Length
- 517 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma fibrinogen
- UniProt
- P02679
- Ligands
- CA
- Pockets
- 3 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 14% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gamma fibrinogen | protein | 260 | 15% helix, 29% strand | P02679 |
| B | Gamma fibrinogen | protein | 257 | 14% helix, 29% strand | P02679 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 556 | 0.70 | 0.79 | 56 | empty |
| 2 | 260 | 0.57 | 0.78 | 43 | empty |
| 3 | 122 | 0.41 | 0.75 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 910 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1FIC · Structure of human gamma fibrinogen 30 kd carboxyl terminal fragment · the same entry in another collection · chain A against A, TM-score 1.00
- P02679 · AlphaFold monomer V2.0 prediction for fibrinogen gamma chain (P02679) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02679
- Elsewhere: RCSB PDB 1FIC · PDBe 1FIC · UniProt P02679
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