MolNFT v1 · #66185 · protein
Crystal structure of P110ALPHA H1047R mutant in complex with NISH2 of P85ALPHA
3HIZ · Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic…: “Crystal structure of P110ALPHA H1047R mutant in complex with NISH2 of P85ALPHA”. X-ray diffraction, 20 pockets (best druggability 0.86). MolNFT v1 #66185 on GenesisL1: 3D…
- PDB
- 3HIZ
- Type
- protein
- Length
- 1,258 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform…
- EC
- 2.7.1.153
- UniProt
- P42336, P27986
- Pockets
- 20 · best druggability 0.86
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) | protein | 1024 | 37% helix, 15% strand | P42336 |
| B | Phosphatidylinositol 3-kinase regulatory subunit alpha | protein | 234 | 53% helix, 9% strand | P27986 |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1121 | 0.86 | 0.86 | 102 | empty |
| 2 | 464 | 0.81 | 0.88 | 56 | empty |
| 3 | 384 | 0.80 | 0.89 | 50 | empty |
| 4 | 291 | 0.78 | 0.90 | 56 | empty |
| 5 | 91 | 0.66 | 0.91 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 3137 Ų buried · 33 hydrogen bonds · protein-protein
Compared structures
- 3HIZ · Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha · the same entry in another collection · chain A against A, TM-score 1.00
- P42336 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 4,5-bisphosphate 3-kinase… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42336
- Every structure of UniProt P27986
- Elsewhere: RCSB PDB 3HIZ · PDBe 3HIZ · UniProt P42336 · UniProt P27986
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