MolNFT v1 · #66171 · protein
Structure of human PLK1-pbd in complex with plhspt
3HIK · SERINE/THREONINE-protein kinase PLK1: “Structure of human PLK1-pbd in complex with plhspt”. X-ray diffraction, 1 ligand (ACE), 2 pockets (best druggability 0.38). MolNFT v1 #66171 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3HIK
- Type
- protein
- Length
- 229 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase PLK1; Pentamer phosphopeptide
- EC
- 2.7.11.21
- UniProt
- P53350
- Ligands
- ACE
- Pockets
- 2 · best druggability 0.38
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase PLK1 (EC 2.7.11.21) | protein | 224 | 32% helix, 29% strand | P53350 |
| B | Pentamer phosphopeptide | protein | 5 | 0% helix, 20% strand | — |
Ligands and binding sites
- ACE · Acetyl group · ligand · chains A, B
- GOL · Glycerol · additive · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 83 | 0.38 | 0.77 | 22 | empty |
| 2 | 61 | 0.36 | 0.79 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 444 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 covalent, 1 modified (covalent ligand, phosphorylation).
Compared structures
- 3HIK · Structure of human Plk1-PBD in complex with PLHSpT · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53350
- Elsewhere: RCSB PDB 3HIK · PDBe 3HIK · UniProt P53350
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