MolNFT v1 · #66160 · protein
The X-ray crystal structure of the first RNA recognition motif (RRM1) of the au-rich element (are) binding protein hur at 2.0 ångström resolution
3HI9 · Elav-like protein 1: “The X-ray crystal structure of the first RNA recognition motif (RRM1) of the au-rich element (are) binding…”. X-ray diffraction, 2 pockets (best druggability 0.73). MolNFT v1 #66160 on GenesisL1: 3D structure…
- PDB
- 3HI9
- Type
- protein
- Length
- 315 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Elav-like protein 1
- UniProt
- Q15717
- Pockets
- 2 · best druggability 0.73
Structure
x-ray diffraction · 3 distinct chains · 25% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Elav-like protein 1 | protein | 79 | 25% helix, 38% strand | Q15717 |
| B | Elav-like protein 1 | protein | 75 | 27% helix, 33% strand | Q15717 |
| D | Elav-like protein 1 | protein | 82 | 24% helix, 37% strand | Q15717 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 460 | 0.73 | 0.83 | 47 | empty |
| 2 | 50 | 0.30 | 0.77 | 18 | empty |
Interfaces
5 interfaces between chains.
- C–D · 541 Ų buried · 1 hydrogen bond · protein-protein
- A–B · 508 Ų buried · 1 hydrogen bond · protein-protein
- B–D · 430 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 306 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 21 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3HI9 · The x-ray crystal structure of the first RNA recognition motif (RRM1) of the AU-rich… · the same entry in another collection · chain D against D, TM-score 1.00
- Q15717 · AlphaFold monomer V2.0 prediction for elav-like protein 1 (Q15717) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15717
- Elsewhere: RCSB PDB 3HI9 · PDBe 3HI9 · UniProt Q15717
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