MolNFT v1 · #6570 · protein

Lipoxygenase-1 (soybean) at 100K, Q495E mutant

1FGQ · Seed lipoxygenase-1: “Lipoxygenase-1 (soybean) at 100K, Q495E mutant”. X-ray diffraction, 1 ligand (FE), 14 pockets (best druggability 0.83). MolNFT v1 #6570 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1FGQ
Type: protein
Length: 820 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Seed lipoxygenase-1
EC: 1.13.11.12
UniProt: P08170
Ligands: FE
Pockets: 14 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Seed lipoxygenase-1 (EC 1.13.11.12)	protein	820	42% helix, 15% strand	P08170

Ligands and binding sites

FE · Fe (III) ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

14 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	591	0.83	0.88	57	empty
2	58	0.72	0.98	23	empty
3	397	0.69	0.81	39	empty
4	225	0.51	0.76	34	empty
5	177	0.46	0.75	28	empty

Compared structures

1FGQ · Lipoxygenase-1 (soybean) at 100K, Q495E mutant · the same entry in another collection · chain A against A, TM-score 1.00
P08170 · AlphaFold monomer V2.0 prediction for seed linoleate 13S-lipoxygenase-1 (P08170) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08170
Elsewhere: RCSB PDB 1FGQ · PDBe 1FGQ · UniProt P08170

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