MolNFT v1 · #65654 · protein
The complex structure of cca-adding enzyme with CTP
3H3A · TRNA nucleotidyl transferase-related protein: “The complex structure of cca-adding enzyme with CTP”. X-ray diffraction, 1 ligand (CTP), 6 pockets (best druggability 0.63). MolNFT v1 #65654 on GenesisL1: 3D structure, binding sites…
- PDB
- 3H3A
- Type
- protein
- Length
- 835 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TRNA nucleotidyl transferase-related protein
- EC
- 2.7.7.25
- UniProt
- Q9WZH4
- Ligands
- CTP
- Pockets
- 6 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 56% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TRNA nucleotidyl transferase-related protein (EC 2.7.7.25) | protein | 417 | 56% helix, 9% strand | Q9WZH4 |
| B | TRNA nucleotidyl transferase-related protein (EC 2.7.7.25) | protein | 418 | 55% helix, 11% strand | Q9WZH4 |
Ligands and binding sites
- CTP · Cytidine-5'-triphosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 381 | 0.63 | 0.77 | 33 | empty |
| 2 | 302 | 0.50 | 0.73 | 40 | CTP |
| 3 | 79 | 0.47 | 0.82 | 18 | empty |
| 4 | 124 | 0.43 | 0.76 | 21 | empty |
| 5 | 166 | 0.38 | 0.72 | 22 | CTP |
Interfaces
1 interface between chains.
- A–B · 707 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 3H3A · The complex structure of CCA-adding enzyme with CTP · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WZH4
- Elsewhere: RCSB PDB 3H3A · PDBe 3H3A · UniProt Q9WZH4
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