MolNFT v1 · #6542 · protein
Chey-binding domain of chea in complex with chey with a bound imido diphosphate
1FFW · Chemotaxis protein chey: “Chey-binding domain of chea in complex with chey with a bound imido diphosphate”. X-ray diffraction, 2 ligands (PON, MN), 5 pockets (best druggability 0.50). MolNFT v1 #6542 on GenesisL1: 3D structure…
- PDB
- 1FFW
- Type
- protein
- Length
- 392 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chemotaxis protein chey; Chemotaxis protein chea
- EC
- 2.7.3.-
- UniProt
- P07363
- Ligands
- PON, MN
- Pockets
- 5 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Chemotaxis protein chey | protein | 128 | 44% helix, 17% strand | P07363 |
| B, D | Chemotaxis protein chea (EC 2.7.3.-) | protein | 68 | 34% helix, 32% strand | P07363 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 146 | 0.50 | 0.79 | 24 | empty |
| 2 | 174 | 0.48 | 0.76 | 26 | empty |
| 3 | 149 | 0.47 | 0.77 | 24 | empty |
| 4 | 69 | 0.31 | 0.74 | 13 | empty |
| 5 | 63 | 0.29 | 0.74 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–B · 613 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 599 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 247 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 1FFW · Chey-binding domain of chea in complex with chey with a bound imido diphosphate · the same entry in another collection · chain D against D, TM-score 1.00
- P07363 · AlphaFold monomer V2.0 prediction for chemotaxis protein chea (P07363) · a predicted model of the same protein · chain D against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07363
- Elsewhere: RCSB PDB 1FFW · PDBe 1FFW · UniProt P07363
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