MolNFT v1 · #65298 · protein

Structure of the genotype 2B HCV polymerase

3GSZ · RNA-directed RNA polymerase: “Structure of the genotype 2B HCV polymerase”. X-ray diffraction, 12 pockets (best druggability 0.80). MolNFT v1 #65298 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3GSZ
Type: protein
Length: 1,116 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-directed RNA polymerase
UniProt: P26661
Pockets: 12 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 51% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	RNA-directed RNA polymerase	protein	558	51% helix, 15% strand	P26661

Pockets

12 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1054	0.80	0.81	85	empty
2	1025	0.79	0.81	91	empty
3	1162	0.75	0.78	73	empty
4	60	0.46	0.83	13	empty
5	127	0.44	0.77	26	empty

Interfaces

1 interface between chains.

A–B · 410 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

3GSZ · Structure of the genotype 2B HCV polymerase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P26661
Elsewhere: RCSB PDB 3GSZ · PDBe 3GSZ · UniProt P26661

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