Research workbench
Structure of the genotype 2B HCV polymerase
Analyse Structure of the genotype 2B HCV polymerase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3GSZ
- Type
- protein
- Length
- 1,116 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-directed RNA polymerase
- UniProt
- P26661
- Pockets
- 12 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 51% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | RNA-directed RNA polymerase | protein | 558 | 51% helix, 15% strand | P26661 |
Pockets
12 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1054 | 0.80 | 0.81 | 85 | empty |
| 2 | 1025 | 0.79 | 0.81 | 91 | empty |
| 3 | 1162 | 0.75 | 0.78 | 73 | empty |
| 4 | 60 | 0.46 | 0.83 | 13 | empty |
| 5 | 127 | 0.44 | 0.77 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 410 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 3GSZ · Structure of the genotype 2B HCV polymerase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26661
- Elsewhere: RCSB PDB 3GSZ · PDBe 3GSZ · UniProt P26661
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