MolNFT v1 · #65156 · protein
Crystal structure of the EGF receptor juxtamembrane and kinase domains
3GOP · Epidermal growth factor receptor: “Crystal structure of the EGF receptor juxtamembrane and kinase domains”. X-ray diffraction, 2 pockets (best druggability 0.49). MolNFT v1 #65156 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3GOP
- Type
- protein
- Length
- 300 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Epidermal growth factor receptor
- EC
- 2.7.10.1
- UniProt
- P00533
- Pockets
- 2 · best druggability 0.49
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Epidermal growth factor receptor (EC 2.7.10.1) | protein | 300 | 43% helix, 15% strand | P00533 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 175 | 0.49 | 0.77 | 30 | empty |
| 2 | 99 | 0.46 | 0.80 | 21 | empty |
Compared structures
- 3GOP · Crystal structure of the EGF receptor juxtamembrane and kinase domains · the same entry in another collection · chain A against A, TM-score 1.00
- P00533 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor (P00533) · a predicted model of the same protein · chain A against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00533
- Elsewhere: RCSB PDB 3GOP · PDBe 3GOP · UniProt P00533
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