MolNFT v1 · #64988 · protein
Crystal structure of human EB1 in complex with microtubule tip localization signal peptide of macf
3GJO · Microtubule-associated protein RP/EB family member 1: “Crystal structure of human EB1 in complex with microtubule tip localization signal peptide of macf”. X-ray diffraction, 2 pockets (best druggability 0.54). MolNFT v1 #64988 on…
- PDB
- 3GJO
- Type
- protein
- Length
- 282 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Microtubule-associated protein RP/EB family member 1; Dystonin
- UniProt
- Q15691, Q5TBT1
- Pockets
- 2 · best druggability 0.54
Structure
x-ray diffraction · 8 distinct chains · 68% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Microtubule-associated protein RP/EB family member 1 | protein | 66 | 73% helix, 3% strand | Q15691 |
| B | Microtubule-associated protein RP/EB family member 1 | protein | 64 | 75% helix, 2% strand | Q15691 |
| C | Microtubule-associated protein RP/EB family member 1 | protein | 65 | 72% helix, 3% strand | Q15691 |
| D | Microtubule-associated protein RP/EB family member 1 | protein | 54 | 89% helix, 0% strand | Q15691 |
| E | Dystonin | protein | 11 | 0% helix, 18% strand | Q5TBT1 |
| F | Dystonin | protein | 9 | 0% helix, 11% strand | Q5TBT1 |
| G | Dystonin | protein | 8 | 0% helix, 25% strand | Q5TBT1 |
| H | Dystonin | protein | 5 | 0% helix, 0% strand | Q5TBT1 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 328 | 0.54 | 0.74 | 36 | empty |
| 2 | 96 | 0.34 | 0.73 | 20 | empty |
Interfaces
15 interfaces between chains.
- A–B · 1754 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 1692 Ų buried · 11 hydrogen bonds · protein-protein
- A–E · 594 Ų buried · 7 hydrogen bonds · protein-protein
- C–G · 583 Ų buried · 4 hydrogen bonds · protein-protein
- B–F · 540 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 3GJO · Crystal structure of human EB1 in complex with microtubule Tip localization signal… · the same entry in another collection · chain H against H, TM-score 1.00
- Q15691 · AlphaFold monomer V2.0 prediction for microtubule-associated protein RP/EB family member… · a predicted model of the same protein · chain B against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15691
- Every structure of UniProt Q5TBT1
- Elsewhere: RCSB PDB 3GJO · PDBe 3GJO · UniProt Q15691 · UniProt Q5TBT1
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.