MolNFT v1 · #6448 · protein
Crystal structure of bee venom hyaluronidase in complex with hyaluronic acid tetramer
1FCV · Hyaluronoglucosaminidase: “Crystal structure of bee venom hyaluronidase in complex with hyaluronic acid tetramer”. X-ray diffraction, 2 ligands (NAG, GCU), 1 pocket (best druggability 0.47). MolNFT v1 #6448 on GenesisL1: 3D…
- PDB
- 1FCV
- Type
- protein
- Length
- 324 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hyaluronoglucosaminidase
- EC
- 3.2.1.35
- UniProt
- Q08169
- Ligands
- NAG, GCU
- Pockets
- 1 · best druggability 0.47
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hyaluronoglucosaminidase (EC 3.2.1.35) | protein | 324 | 47% helix, 15% strand | Q08169 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
- GCU · alpha-D-glucopyranuronic acid · ion · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 175 | 0.47 | 0.76 | 27 | GCU |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1FCV · Crystal structure of bee venom hyaluronidase in complex with hyaluronic acid tetramer · the same entry in another collection · chain A against A, TM-score 1.00
- Q08169 · AlphaFold monomer V2.0 prediction for hyaluronidase (Q08169) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q08169
- Elsewhere: RCSB PDB 1FCV · PDBe 1FCV · UniProt Q08169
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