Research workbench
Crystal structure of bee venom hyaluronidase in complex with hyaluronic acid tetramer
Analyse Crystal structure of bee venom hyaluronidase in complex with hyaluronic acid… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1FCV
- Type
- protein
- Length
- 324 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hyaluronoglucosaminidase
- EC
- 3.2.1.35
- UniProt
- Q08169
- Ligands
- NAG, GCU
- Pockets
- 1 · best druggability 0.47
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hyaluronoglucosaminidase (EC 3.2.1.35) | protein | 324 | 47% helix, 15% strand | Q08169 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
- GCU · alpha-D-glucopyranuronic acid · ion · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 175 | 0.47 | 0.76 | 27 | GCU |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1FCV · Crystal structure of bee venom hyaluronidase in complex with hyaluronic acid tetramer · the same entry in another collection · chain A against A, TM-score 1.00
- Q08169 · AlphaFold monomer V2.0 prediction for hyaluronidase (Q08169) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q08169
- Elsewhere: RCSB PDB 1FCV · PDBe 1FCV · UniProt Q08169
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