MolNFT v1 · #64313 · protein

Crystal structure of PYK2-apo, proline-rich tyrosine kinase

3FZO · Protein tyrosine kinase 2 beta: “Crystal structure of PYK2-apo, proline-rich tyrosine kinase”. X-ray diffraction, 1 pocket (best druggability 0.65). MolNFT v1 #64313 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3FZO
Type: protein
Length: 262 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein tyrosine kinase 2 beta
EC: 2.7.10.2
UniProt: Q14289
Pockets: 1 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein tyrosine kinase 2 beta (EC 2.7.10.2)	protein	262	46% helix, 18% strand	Q14289

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	387	0.65	0.79	45	empty

Compared structures

3FZO · Crystal Structure of PYK2-Apo, Proline-rich Tyrosine Kinase · the same entry in another collection · chain A against A, TM-score 1.00
Q14289 · AlphaFold monomer V2.0 prediction for protein-tyrosine kinase 2-beta (Q14289) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14289
Elsewhere: RCSB PDB 3FZO · PDBe 3FZO · UniProt Q14289

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