UniProt Q14289
Protein-tyrosine kinase 2-beta (Q14289)
Protein-tyrosine kinase 2-beta (UniProt Q14289), EC 2.7.10.2: 46 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q14289
- Protein
- Protein-tyrosine kinase 2-beta
- EC
- 2.7.10.2
- Experimental structures
- 46
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 5 · 3 records with a druggable one
Structures
47 records of Q14289 in the MolNFT archive: 46 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2LK4 | Structural and mechanistic insights into the interaction between PAT Pyk2 and Paxillin LD motif | solution nmr | A | — | — |
| 2LK4 | Structural and mechanistic insights into the interaction between pat PYK2 and paxillin ld motif | solution nmr | A | — | — |
| 3CC6 | Crystal structure of kinase domain of protein tyrosine kinase 2 beta (PTK2B) | x-ray diffraction | A | — | — |
| 3CC6 | Crystal structure of kinase domain of protein tyrosine kinase 2 beta (PTK2B) | x-ray diffraction | A | — | — |
| 3ET7 | Crystal structure of PYK2 complexed with PF-2318841 | x-ray diffraction | A | — | — |
| 3ET7 | Crystal structure of PYK2 complexed with pf-2318841 | x-ray diffraction | A | — | — |
| 3FZO | Crystal Structure of PYK2-Apo, Proline-rich Tyrosine Kinase | x-ray diffraction | A | — | — |
| 3FZO | Crystal structure of PYK2-apo, proline-rich tyrosine kinase | x-ray diffraction | A | — | — |
| 3FZP | Crystal structure of PYK2 complexed with ATPgS | x-ray diffraction | A | — | — |
| 3FZP | Crystal structure of PYK2 complexed with atpgs | x-ray diffraction | A | — | — |
| 3FZR | Crystal structure of PYK2 complexed with PF-431396 | x-ray diffraction | A | — | — |
| 3FZR | Crystal structure of PYK2 complexed with pf-431396 | x-ray diffraction | A | — | — |
| 3FZS | Crystal Structure of PYK2 complexed with BIRB796 | x-ray diffraction | A | — | — |
| 3FZS | Crystal structure of PYK2 complexed with BIRB796 | x-ray diffraction | A | — | — |
| 3FZT | Crystal structure of PYK2 complexed with PF-4618433 | x-ray diffraction | A | — | — |
| 3FZT | Crystal structure of PYK2 complexed with pf-4618433 | x-ray diffraction | A | — | — |
| 3GM1 | Crystal Structure of the Focal Adhesion Targeting (FAT) Domain of Pyk2 in Complex with Paxillin LD4… | x-ray diffraction | A, B | — | — |
| 3GM1 | Crystal structure of the focal adhesion targeting (fat) domain of PYK2 in complex with paxillin LD4… | x-ray diffraction | A, B | — | — |
| 3GM2 | Crystal Structure of the Focal Adhesion Targeting (FAT) Domain of Pyk2 | x-ray diffraction | A | — | — |
| 3GM2 | Crystal structure of the focal adhesion targeting (fat) domain of PYK2 | x-ray diffraction | A | — | — |
| 3GM3 | Crystal Structure of the Focal Adhesion Targeting (FAT) Domain of Pyk2 | x-ray diffraction | A | — | — |
| 3GM3 | Crystal structure of the focal adhesion targeting (fat) domain of PYK2 | x-ray diffraction | A | — | — |
| 3H3C | Crystal structure of PYK2 in complex with Sulfoximine-substituted trifluoromethylpyrimidine analog | x-ray diffraction | A | — | — |
| 3H3C | Crystal structure of PYK2 in complex with sulfoximine- substituted trifluoromethylpyrimidine analog | x-ray diffraction | A | — | — |
| 3U3F | Structural basis for the interaction of Pyk2 PAT domain with paxillin LD motifs | x-ray diffraction | A, B, C, D | — | — |
| 3U3F | Structural basis for the interaction of PYK2 pat domain with paxillin ld motifs | x-ray diffraction | A, B, C, D | — | — |
| 4EKU | Crystal Structure of FERM Domain of Proline-rich Tyrosine Kinase 2 | x-ray diffraction | A | — | — |
| 4EKU | Crystal structure of ferm domain of proline-rich tyrosine kinase 2 | x-ray diffraction | A | — | — |
| 4H1J | Crystal structure of PYK2 with the pyrazole 13a | x-ray diffraction | A | — | — |
| 4H1J | Crystal structure of PYK2 with the pyrazole 13A | x-ray diffraction | A | — | — |
| 4H1M | Crystal structure of PYK2 with the indole 10c | x-ray diffraction | A | — | — |
| 4H1M | Crystal structure of PYK2 with the indole 10C | x-ray diffraction | A | — | — |
| 4R32 | Crystal Structure Analysis of Pyk2 and Paxillin LD motifs | x-ray diffraction | A | — | — |
| 4R32 | Crystal structure analysis of PYK2 and paxillin ld motifs | x-ray diffraction | A | — | — |
| 4XEF | Pyk2-FAT complexed with Leupaxin LD motif LD1 | x-ray diffraction | A, D | — | — |
| 4XEF | PYK2-fat complexed with leupaxin ld motif LD1 | x-ray diffraction | A, D | — | — |
| 4XEK | Pyk2-FAT domain in complex with leupaxin LD4 motif | x-ray diffraction | A | — | — |
| 4XEK | PYK2-fat domain in complex with leupaxin LD4 motif | x-ray diffraction | A | — | — |
| 4XEV | Fusion of Pyk2-FAT domain with Leupaxin LD1 motif, complexed with Leupaxin LD4 peptide | x-ray diffraction | A, D | — | — |
| 4XEV | Fusion of PYK2-fat domain with leupaxin LD1 motif, complexed with leupaxin LD4 peptide | x-ray diffraction | A, D | — | — |
| 5TO8 | Selectivity switch between fak and PYK2: macrocyclization of fak inhibitors improves PYK2 potency | x-ray diffraction | A | 7FM | — |
| 5TOB | Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency | x-ray diffraction | A | YAM | 1 (best 0.63) |
| 5TOB | Selectivity switch between fak and PYK2: macrocyclization of fak inhibitors improves PYK2 potency | x-ray diffraction | A | YAM | — |
| 6LF3 | 3D domain-swapped dimer of the maltose-binding protein fused to a fragment of the protein-tyrosine… | x-ray diffraction | A, B, C, D, E, F | GLC | — |
| 8XOX | The Crystal Structure of FAK2 from Biortus. | x-ray diffraction | A | YAM | 2 (best 0.69) |
| 8YGX | Structure of the PYK2 from Biortus. | x-ray diffraction | A | — | 2 (best 0.67) |
| Q14289 | AlphaFold monomer V2.0 prediction for protein-tyrosine kinase 2-beta (Q14289) | predicted | A | — | — |
Ligands
- YAM · N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl) amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino) methyl]pyridin-2-yl}methanesulfonamide · in 3 records
- 7FM · 25-(methylsulfonyl)-8-(trifluoromethyl)-5,17,18,21,22, 23,24,25-octahydro-12H-7,11-(azeno)-16,13-(metheno) pyrido[3,2-i]pyrrolo[1,2-Q][1,3,7,11, 17]pentaazacyclohenicosin-20(6H)-one · in 1 record
- GLC · alpha-D-glucopyranose · in 1 record
Experiment against prediction
- 3U3F chain C against the predicted model Q14289: TM-score 0.99, RMSD 0.51 Å
- 3U3F chain C against the predicted model Q14289: TM-score 0.99, RMSD 0.51 Å
- 3U3F chain D against the predicted model Q14289: TM-score 0.98, RMSD 0.54 Å
- 3U3F chain D against the predicted model Q14289: TM-score 0.98, RMSD 0.54 Å
- 4EKU chain A against the predicted model Q14289: TM-score 0.98, RMSD 1.01 Å
- 4EKU chain A against the predicted model Q14289: TM-score 0.98, RMSD 1.01 Å
- 5TOB chain A against the predicted model Q14289: TM-score 0.97, RMSD 0.97 Å
- 5TOB chain A against the predicted model Q14289: TM-score 0.97, RMSD 0.97 Å
- 3ET7 chain A against the predicted model Q14289: TM-score 0.97, RMSD 1.09 Å
- 3ET7 chain A against the predicted model Q14289: TM-score 0.97, RMSD 1.09 Å
Elsewhere
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