YAM · N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl) amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino) methyl]pyridin-2-yl}methanesulfonamide

Binding sites

YAM in 5 structures; the first of them:

• 5TOB · Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2… · YAM A701 · binds LEU431, GLY432, GLU433, GLY434, VAL439, ALA455, LYS457, VAL487 and 11 more
• 5X4O · Crystal structure of the BCL6 BTB domain in complex with Compound 5 · YAM A801 · binds ASN21, ARG24, LEU25, ARG28
• 8XOX · The Crystal Structure of FAK2 from Biortus. · YAM A701 · binds LEU431, GLY432, GLU433, GLY434, VAL439, ALA455, LYS457, VAL487 and 11 more
• 5TOB · Selectivity switch between fak and PYK2: macrocyclization of fak inhibitors improves PYK2… · YAM A701 · binds LEU431, GLY432, GLU433, VAL439, VAL487, MET502, GLU503, LEU504 and 7 more
• 5X4O · Crystal structure of the BCL6 btb domain in complex with compound 5 · YAM A801 · binds ASN21, ARG24, LEU25, ARG28

Residues it binds most

LEU 5, GLU 3, GLY 3, ARG 5, VAL 3, ASN 5, ASP 3, MET 3, TYR 3, ALA 2 (residue and the binding sites it lines).

Found with

• EDO · 1,2-ethanediol