MolNFT v1 · #64200 · protein

SAC3:SUS1:CDC31 complex

3FWC · Cell division control protein 31: “SAC3:SUS1:CDC31 complex”. X-ray diffraction, 1 ligand (SO4), 19 pockets (best druggability 0.57). MolNFT v1 #64200 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3FWC
Type: protein
Length: 1,626 residues
Chains: 16
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cell division control protein 31; Nuclear mRNA export protein SAC3; Protein SUS1
UniProt: P06704, P46674, Q6WNK7
Ligands: SO4
Pockets: 19 · best druggability 0.57

Structure

x-ray diffraction · 14 distinct chains · 75% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cell division control protein 31	protein	145	58% helix, 6% strand	P06704
B	Nuclear mRNA export protein SAC3	protein	83	94% helix, 0% strand	P46674
C	Protein SUS1	protein	87	77% helix, 0% strand	Q6WNK7
D	Protein SUS1	protein	86	81% helix, 0% strand	Q6WNK7
E	Cell division control protein 31	protein	150	59% helix, 5% strand	P06704
F, N	Nuclear mRNA export protein SAC3	protein	84	96% helix, 0% strand	P46674
G, K	Protein SUS1	protein	88	78% helix, 0% strand	Q6WNK7
H	Protein SUS1	protein	92	82% helix, 0% strand	Q6WNK7
I	Cell division control protein 31	protein	147	61% helix, 4% strand	P06704
J	Nuclear mRNA export protein SAC3	protein	78	97% helix, 0% strand	P46674
L	Protein SUS1	protein	84	81% helix, 0% strand	Q6WNK7
M	Cell division control protein 31	protein	148	60% helix, 5% strand	P06704
O	Protein SUS1	protein	89	82% helix, 0% strand	Q6WNK7
P	Protein SUS1	protein	93	83% helix, 0% strand	Q6WNK7

Ligands and binding sites

SO4 · Sulfate ion · ion · 4 copies · chains A, B, C, E, F, G, I, J, K, M, N, O

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

19 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	210	0.57	0.79	25	SO4
2	203	0.54	0.78	28	SO4
3	197	0.53	0.78	26	SO4
4	266	0.52	0.75	37	empty
5	174	0.51	0.78	23	SO4

Interfaces

23 interfaces between chains.

J–K · 1658 Å² buried · 8 hydrogen bonds · protein-protein
F–G · 1645 Å² buried · 9 hydrogen bonds · protein-protein
N–O · 1644 Å² buried · 10 hydrogen bonds · protein-protein
B–C · 1615 Å² buried · 7 hydrogen bonds · protein-protein
M–N · 1518 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

3FWC · Sac3:Sus1:Cdc31 complex · the same entry in another collection · chain G against G, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06704
Every structure of UniProt P46674
Every structure of UniProt Q6WNK7
Elsewhere: RCSB PDB 3FWC · PDBe 3FWC · UniProt P06704 · UniProt P46674 · UniProt Q6WNK7

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