MolNFT v1 · #64169 · protein
Polo-like kinase 1 polo box domain in complex with ac-lhspta-NH2 peptide
3FVH · SERINE/THREONINE-protein kinase PLK1: “Polo-like kinase 1 polo box domain in complex with ac-lhspta-NH2 peptide”. X-ray diffraction, 2 ligands (ACE, NH2), 3 pockets (best druggability 0.43). MolNFT v1 #64169 on GenesisL1: 3D…
- PDB
- 3FVH
- Type
- protein
- Length
- 238 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase PLK1; Acetyl-leu-his-ser-phosphothr-ala-NH2 peptide
- EC
- 2.7.11.21
- UniProt
- P53350
- Ligands
- ACE, NH2
- Pockets
- 3 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase PLK1 (EC 2.7.11.21) | protein | 233 | 34% helix, 28% strand | P53350 |
| B | Acetyl-leu-his-ser-phosphothr-ala-NH2 peptide | protein | 5 | 0% helix, 20% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 57 | 0.43 | 0.83 | 18 | empty |
| 2 | 60 | 0.37 | 0.79 | 18 | empty |
| 3 | 79 | 0.29 | 0.72 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 414 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 covalent, 1 modified (covalent ligand, phosphorylation).
Compared structures
- 3FVH · Polo-like kinase 1 Polo box domain in complex with Ac-LHSpTA-NH2 peptide · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53350
- Elsewhere: RCSB PDB 3FVH · PDBe 3FVH · UniProt P53350
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.