MolNFT v1 · #64073 · protein
Crystal structure of RPE65 at 2.14 ångström resolution
3FSN · Retinal pigment epithelium-specific 65 kda protein: “Crystal structure of RPE65 at 2.14 ångström resolution”. X-ray diffraction, 1 ligand (FE2), 8 pockets (best druggability 0.84). MolNFT v1 #64073 on GenesisL1: 3D structure…
- PDB
- 3FSN
- Type
- protein
- Length
- 1,027 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Retinal pigment epithelium-specific 65 kda protein
- EC
- 5.2.1.7
- UniProt
- Q28175
- Ligands
- FE2
- Pockets
- 8 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 11% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Retinal pigment epithelium-specific 65 kda protein (EC 5.2.1.7) | protein | 513 | 11% helix, 44% strand | Q28175 |
| B | Retinal pigment epithelium-specific 65 kda protein (EC 5.2.1.7) | protein | 514 | 11% helix, 44% strand | Q28175 |
Ligands and binding sites
- FE2 · Fe (II) ion · metal · 2 copies · chains A, B
- PG4 · Tetraethylene glycol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 588 | 0.84 | 0.88 | 66 | empty |
| 2 | 630 | 0.83 | 0.87 | 79 | empty |
| 3 | 474 | 0.79 | 0.87 | 52 | empty |
| 4 | 594 | 0.78 | 0.84 | 53 | empty |
| 5 | 347 | 0.56 | 0.75 | 55 | empty |
Interfaces
1 interface between chains.
- A–B · 1624 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q28175
- Elsewhere: RCSB PDB 3FSN · PDBe 3FSN · UniProt Q28175
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.