UniProt Q28175
Retinoid isomerohydrolase (Q28175)
Retinoid isomerohydrolase (UniProt Q28175), EC 3.1.1.64, 5.3.3.22: 32 experimental structures and 1 predicted model on GenesisL1, 14 ligands bound, 27 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q28175
- Protein
- Retinoid isomerohydrolase
- EC
- 3.1.1.64, 5.3.3.22
- Experimental structures
- 32
- Predicted models
- 1
- Ligands
- 14
- Pockets
- 27 · 4 records with a druggable one
Structures
33 records of Q28175 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3FSN | Crystal structure of RPE65 at 2.14 angstrom resolution | x-ray diffraction | A, B | — | — |
| 3FSN | Crystal structure of RPE65 at 2.14 ångström resolution | x-ray diffraction | A, B | — | — |
| 3KVC | Crystal structure of bovine RPE65 at 1.9 angstrom resolution | x-ray diffraction | A, B | — | — |
| 3KVC | Crystal structure of bovine RPE65 at 1.9 ångström resolution | x-ray diffraction | A, B | — | — |
| 4F2Z | Crystal structure of RPE65 in a lipid environment | x-ray diffraction | A, E | — | — |
| 4F2Z | Crystal structure of RPE65 in a lipid environment | x-ray diffraction | A, E | — | — |
| 4F30 | Structure of RPE65: P6522 crystal form grown in ammonium phosphate solution | x-ray diffraction | A | — | — |
| 4F30 | Structure of RPE65: P6522 crystal form grown in ammonium phosphate solution | x-ray diffraction | A | — | — |
| 4F3A | Structure of RPE65: P6522 crystal form, iridium derivative | x-ray diffraction | A | — | — |
| 4F3A | Structure of RPE65: P6522 crystal form, iridium derivative | x-ray diffraction | A | — | — |
| 4F3D | Structure of RPE65: P65 crystal form grown in Fos-Choline-10 | x-ray diffraction | A, B | — | — |
| 4F3D | Structure of RPE65: P65 crystal form grown in fos-choline-10 | x-ray diffraction | A, B | — | — |
| 4RSC | Crystal structure of RPE65 in complex with emixustat and palmitate | x-ray diffraction | A, B | — | — |
| 4RSC | Crystal structure of RPE65 in complex with emixustat and palmitate | x-ray diffraction | A, B | — | — |
| 4RSE | Crystal structure of RPE65 in complex with MB-001 and palmitate | x-ray diffraction | A, B | — | — |
| 4RSE | Crystal structure of RPE65 in complex with mb-001 and palmitate | x-ray diffraction | A, B | — | — |
| 4RYX | Crystal structure of RPE65 in complex with emixustat and palmitate, P6522 crystal form | x-ray diffraction | A | — | — |
| 4RYX | Crystal structure of RPE65 in complex with emixustat and palmitate, P6522 crystal form | x-ray diffraction | A | — | — |
| 4RYY | Crystal structure of RPE65 in complex with R-emixustat and palmitate | x-ray diffraction | A, B | — | — |
| 4RYY | Crystal structure of RPE65 in complex with R-emixustat and palmitate | x-ray diffraction | A, B | — | — |
| 4RYZ | Crystal structure of RPE65 in complex with S-emixustat and palmitate | x-ray diffraction | A, B | — | — |
| 4RYZ | Crystal structure of RPE65 in complex with S-emixustat and palmitate | x-ray diffraction | A, B | — | — |
| 4ZHK | Crystal structure of RPE65 in complex with MB-002 | x-ray diffraction | A, B | FE2, NA, A8V, A9V | 11 (best 0.84) |
| 4ZHK | Crystal structure of RPE65 in complex with mb-002 | x-ray diffraction | A, B | — | — |
| 5UL5 | Crystal structure of RPE65 in complex with mb-004 and palmitate | x-ray diffraction | A, B | FE2, PLM, 8D7, NA | — |
| 5ULG | Crystal structure of RPE65 in complex with mb-008 and palmitate | x-ray diffraction | A, B | FE2, PLM, 8E4, NA | — |
| 7K88 | Crystal structure of bovine RPE65 in complex with hexaethylene glycol monooctyl ether | x-ray diffraction | A, B | ACE, FE2, 32M, NA | — |
| 7K89 | Crystal structure of bovine RPE65 in complex with 4-fluoro-emixustat and palmitate | x-ray diffraction | A, B | ACE, FE2, PLM, NA, W4J | — |
| 7K8G | Crystal structure of bovine RPE65 in complex with 4-fluoro-mb-004 and palmitate | x-ray diffraction | A, B | FE2, PLM, W9A | — |
| 7L0E | Crystal structure of bovine RPE65 in complex with gem-difluoro emixustat and palmitate | x-ray diffraction | A, B | FE2, PLM, XQ7, PO4 | 8 (best 0.81) |
| 7L0E | Crystal structure of bovine RPE65 in complex with gem-difluoro emixustat and palmitate | x-ray diffraction | A, B | FE2, PLM, XQ7, PO4 | — |
| 8DOC | Crystal structure of RPE65 in complex with compound 16e and palmitate | x-ray diffraction | A | FE2, PLM, SYL | 3 (best 0.81) |
| Q28175 | AlphaFold monomer V2.0 prediction for retinoid isomerohydrolase (Q28175) | predicted | A | — | 5 (best 0.85) |
Ligands
- FE2 · Fe (II) ion · in 9 records
- PLM · Palmitic acid · in 7 records
- NA · Sodium ion · in 5 records
- ACE · Acetyl group · in 2 records
- PO4 · Phosphate ion · in 2 records
- XQ7 · (1R)-3-amino-1-{3-[(4,4-difluorocyclohexyl) methoxy]phenyl}propan-1-ol · in 2 records
- 32M · 3,6,9,12,15,18-hexaoxahexacosan-1-ol · in 1 record
- 8D7 · (1R)-3-amino-1-{3-[(2-propylpentyl)oxy]phenyl}propan-1-ol · in 1 record
- 8E4 · (3S)-3-({3-[(1R)-3-amino-1-hydroxypropyl]phenoxy}methyl)hexan-1-ol · in 1 record
- A8V · (1S)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol · in 1 record
- A9V · (1R)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol · in 1 record
- SYL · (1R)-1-[3-(cyclohexylmethoxy)phenyl]-3-(methylamino)propan-1-ol · in 1 record
- W4J · (1R)-3-amino-1-[3-(cyclohexylmethoxy)-4-fluorophenyl]propan-1-ol · in 1 record
- W9A · (1R)-3-amino-1-{4-fluoro-3-[(2-propylpentyl) oxy]phenyl}propan-1-ol · in 1 record
Experiment against prediction
- 7K8G chain A against the predicted model Q28175: TM-score 1.00, RMSD 0.22 Å
- 3KVC chain B against the predicted model Q28175: TM-score 1.00, RMSD 0.22 Å
- 3KVC chain B against the predicted model Q28175: TM-score 1.00, RMSD 0.22 Å
- 7L0E chain B against the predicted model Q28175: TM-score 1.00, RMSD 0.22 Å
- 7L0E chain B against the predicted model Q28175: TM-score 1.00, RMSD 0.22 Å
- 7K8G chain B against the predicted model Q28175: TM-score 1.00, RMSD 0.24 Å
- 3KVC chain A against the predicted model Q28175: TM-score 1.00, RMSD 0.25 Å
- 3KVC chain A against the predicted model Q28175: TM-score 1.00, RMSD 0.25 Å
- 7L0E chain A against the predicted model Q28175: TM-score 1.00, RMSD 0.29 Å
- 7L0E chain A against the predicted model Q28175: TM-score 1.00, RMSD 0.29 Å
Elsewhere
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