MolNFT v1 · #64067 · protein
Crystal structure of the ubiquitin conjugating enzyme UBE2G2 bound to the G2BR domain of ubiquitin ligase GP78
3FSH · Ubiquitin-conjugating enzyme E2 G2: “Crystal structure of the ubiquitin conjugating enzyme UBE2G2 bound to the G2BR domain of ubiquitin ligase GP78”. X-ray diffraction, 7 pockets (best druggability 0.56). MolNFT v1 #64067 on…
- PDB
- 3FSH
- Type
- protein
- Length
- 355 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin-conjugating enzyme E2 G2; Autocrine motility factor receptor, isoform 2
- EC
- 6.3.2.19, 6.3.2.-
- UniProt
- P60605, Q9UKV5
- Pockets
- 7 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Ubiquitin-conjugating enzyme E2 G2 (EC 6.3.2.19) | protein | 167 | 37% helix, 16% strand | P60605 |
| C | Autocrine motility factor receptor, isoform 2 (EC 6.3.2.-) | protein | 21 | 76% helix, 0% strand | Q9UKV5 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 214 | 0.56 | 0.79 | 34 | empty |
| 2 | 130 | 0.40 | 0.75 | 23 | empty |
| 3 | 120 | 0.40 | 0.76 | 19 | empty |
| 4 | 88 | 0.35 | 0.75 | 20 | empty |
| 5 | 80 | 0.35 | 0.75 | 18 | empty |
Interfaces
3 interfaces between chains.
- B–C · 797 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 626 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 52 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3FSH · Crystal structure of the ubiquitin conjugating enzyme Ube2g2 bound to the G2BR domain of… · the same entry in another collection · chain A against A, TM-score 1.00
- P60605 · AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 G2 (P60605) · a predicted model of the same protein · chain A against A, TM-score 0.94
- Q9UKV5 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase amfr (Q9UKV5) · a predicted model of the same protein · chain C against A, TM-score 0.73
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60605
- Every structure of UniProt Q9UKV5
- Elsewhere: RCSB PDB 3FSH · PDBe 3FSH · UniProt P60605 · UniProt Q9UKV5
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