Research workbench
Crystal structure of the ubiquitin conjugating enzyme UBE2G2 bound to the G2BR domain of ubiquitin ligase GP78
Analyse Crystal structure of the ubiquitin conjugating enzyme UBE2G2 bound to the G2BR… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3FSH
- Type
- protein
- Length
- 355 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin-conjugating enzyme E2 G2; Autocrine motility factor receptor, isoform 2
- EC
- 6.3.2.19, 6.3.2.-
- UniProt
- P60605, Q9UKV5
- Pockets
- 7 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Ubiquitin-conjugating enzyme E2 G2 (EC 6.3.2.19) | protein | 167 | 37% helix, 16% strand | P60605 |
| C | Autocrine motility factor receptor, isoform 2 (EC 6.3.2.-) | protein | 21 | 76% helix, 0% strand | Q9UKV5 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 214 | 0.56 | 0.79 | 34 | empty |
| 2 | 130 | 0.40 | 0.75 | 23 | empty |
| 3 | 120 | 0.40 | 0.76 | 19 | empty |
| 4 | 88 | 0.35 | 0.75 | 20 | empty |
| 5 | 80 | 0.35 | 0.75 | 18 | empty |
Interfaces
3 interfaces between chains.
- B–C · 797 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 626 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 52 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3FSH · Crystal structure of the ubiquitin conjugating enzyme Ube2g2 bound to the G2BR domain of… · the same entry in another collection · chain A against A, TM-score 1.00
- P60605 · AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 G2 (P60605) · a predicted model of the same protein · chain A against A, TM-score 0.94
- Q9UKV5 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase amfr (Q9UKV5) · a predicted model of the same protein · chain C against A, TM-score 0.73
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60605
- Every structure of UniProt Q9UKV5
- Elsewhere: RCSB PDB 3FSH · PDBe 3FSH · UniProt P60605 · UniProt Q9UKV5
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