MolNFT v1 · #64047 · protein
Crystal structure of the yeast orthologue of RACK1, ASC1.
3FRX · Guanine nucleotide-binding protein subunit beta- like…: “Crystal structure of the yeast orthologue of RACK1, ASC1.”. X-ray diffraction, 1 ligand (MN), 6 pockets (best druggability 0.79). MolNFT v1 #64047 on GenesisL1: 3D structure…
- PDB
- 3FRX
- Type
- protein
- Length
- 1,242 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein subunit beta- like protein
- UniProt
- P38011
- Ligands
- MN
- Pockets
- 6 · best druggability 0.79
Structure
x-ray diffraction · 4 distinct chains · 0% helix, 57% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein subunit beta- like protein | protein | 309 | 1% helix, 59% strand | P38011 |
| B | Guanine nucleotide-binding protein subunit beta- like protein | protein | 313 | 0% helix, 57% strand | P38011 |
| C | Guanine nucleotide-binding protein subunit beta- like protein | protein | 308 | 0% helix, 57% strand | P38011 |
| D | Guanine nucleotide-binding protein subunit beta- like protein | protein | 312 | 0% helix, 56% strand | P38011 |
Ligands and binding sites
- MN · Manganese (II) ion · metal · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 763 | 0.79 | 0.83 | 63 | MN |
| 2 | 776 | 0.79 | 0.82 | 64 | MN |
| 3 | 797 | 0.79 | 0.82 | 64 | MN |
| 4 | 779 | 0.79 | 0.82 | 64 | MN |
| 5 | 58 | 0.33 | 0.77 | 17 | empty |
Modifications
Observed in the structure: 25 modified (engineered).
Compared structures
- 3FRX · Crystal Structure of the Yeast Orthologue of RACK1, Asc1. · the same entry in another collection · chain D against D, TM-score 1.00
- P38011 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein subunit… · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38011
- Elsewhere: RCSB PDB 3FRX · PDBe 3FRX · UniProt P38011
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