Chimera of alcohol dehydrogenase by exchange of the cofactor binding domain res 153-295 of C. beijerinckii adh by T. brockii adh

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 24% strand (DSSP).

Ligands and binding sites

• ZN · Zinc ion · metal · chains A
• CL · Chloride ion · ion · 2 copies · chains A
• EDO · 1,2-ethanediol · additive · chains A
• CAC · Cacodylate ion · additive · chains A
• PGE · Triethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 3FPL · Chimera of alcohol dehydrogenase by exchange of the cofactor binding domain res 153-295… · the same entry in another collection · chain A against A, TM-score 1.00
• P25984 · AlphaFold monomer V2.0 prediction for NADP-dependent isopropanol dehydrogenase (P25984) · a predicted model of the same protein · chain A against A, TM-score 1.00
• P14941 · AlphaFold monomer V2.0 prediction for NADP-dependent isopropanol dehydrogenase (P14941) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P25984
• Every structure of UniProt P14941
• Elsewhere: RCSB PDB 3FPL · PDBe 3FPL · UniProt P25984 · UniProt P14941