UniProt P14941
NADP-dependent isopropanol dehydrogenase (P14941)
NADP-dependent isopropanol dehydrogenase (UniProt P14941), EC 1.1.1.80: 24 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 44 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P14941
- Protein
- NADP-dependent isopropanol dehydrogenase
- EC
- 1.1.1.80
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 44 · 3 records with a druggable one
Structures
25 records of P14941 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BXZ | Crystal structure of a thermophilic alcohol dehydrogenase substrate complex from thermoanaerobacter… | x-ray diffraction | A, B, C, D | — | — |
| 1BXZ | Crystal structure of a thermophilic alcohol dehydrogenase substrate complex from thermoanaerobacter… | x-ray diffraction | A, B, C, D | — | — |
| 1YKF | NADP-dependent alcohol dehydrogenase from thermoanaerobium brockii | x-ray diffraction | A, B, C, D | — | — |
| 1YKF | NADP-dependent alcohol dehydrogenase from thermoanaerobium brockii | x-ray diffraction | A, B, C, D | — | — |
| 2NVB | Contribution of Pro275 to the Thermostability of the Alcohol Dehydrogenases (ADHs) | x-ray diffraction | A, B, C, D | — | — |
| 2NVB | Contribution of PRO275 to the thermostability of the alcohol dehydrogenases (adhs) | x-ray diffraction | A, B, C, D | — | — |
| 3FPC | Chimera of alcohol dehydrogenase by exchange of the cofactor binding domain res 153-294 of T.… | x-ray diffraction | A, B, C, D | — | — |
| 3FPC | Chimera of alcohol dehydrogenase by exchange of the cofactor binding domain res 153-294 of T.… | x-ray diffraction | A, B, C, D | — | — |
| 3FPL | Chimera of alcohol dehydrogenase by exchange of the cofactor binding domain res 153-295 of C.… | x-ray diffraction | A | — | — |
| 3FPL | Chimera of alcohol dehydrogenase by exchange of the cofactor binding domain res 153-295 of C.… | x-ray diffraction | A | — | — |
| 3FSR | Chimera of alcohol dehydrogenase by exchange of the cofactor binding domain res 153-295 of T.… | x-ray diffraction | A, B, C, D | — | — |
| 3FSR | Chimera of alcohol dehydrogenase by exchange of the cofactor binding domain res 153-295 of T.… | x-ray diffraction | A, B, C, D | — | — |
| 3FTN | Q165E/S254K Double Mutant Chimera of alcohol dehydrogenase by exchange of the cofactor binding… | x-ray diffraction | A, B, C, D | — | — |
| 3FTN | Q165E/S254K double mutant chimera of alcohol dehydrogenase by exchange of the cofactor binding… | x-ray diffraction | A, B, C, D | — | — |
| 6SDM | NADH-dependent variant of tbadh | x-ray diffraction | A, B, C, D | ZN | — |
| 7F3P | Crystal structure of a NADP-dependent alcohol dehydrogenase mutant in apo form | x-ray diffraction | A, B, C, D | ZN, NAP | — |
| 7UTC | Crystal structure of secondary alcohol dehydrogenases from the Thermoanaerobacter ethanolicus with… | x-ray diffraction | A, B, C, D | ZN, NAP | — |
| 7UTC | Crystal structure of secondary alcohol dehydrogenases from the thermoanaerobacter ethanolicus with… | x-ray diffraction | A, B, C, D | ZN, NAP | — |
| 7UUT | Ternary complex crystal structure of secondary alcohol dehydrogenases from the Thermoanaerobacter… | x-ray diffraction | A, B, C, D | ZN, NAP, 2RP, K | — |
| 7UUT | Ternary complex crystal structure of secondary alcohol dehydrogenases from the thermoanaerobacter… | x-ray diffraction | A, B, C, D | ZN, NAP, 2RP, K | — |
| 7UX4 | Crystallographic snapshots of ternary complexes of thermophilic secondary alcohol dehydrogenase… | x-ray diffraction | A, B, C, D | ZN, NAP, K, NWO, CL | 13 (best 0.75) |
| 7UX4 | Crystallographic snapshots of ternary complexes of thermophilic secondary alcohol dehydrogenase… | x-ray diffraction | A, B, C, D | ZN, NAP, K, NWO, CL | — |
| 7XL5 | Crystal structure of the H42T/A85G/I86A mutant of a nadp-dependent alcohol dehydrogenase | x-ray diffraction | A, B, C, D | — | 16 (best 0.85) |
| 7XY9 | Cryo-EM structure of secondary alcohol dehydrogenases TbSADH after carrier-free immobilization… | electron microscopy | A, B, C, D | ZN, MG | 15 (best 0.87) |
| P14941 | AlphaFold monomer V2.0 prediction for NADP-dependent isopropanol dehydrogenase (P14941) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7UTC chain D against the predicted model P14941: TM-score 1.00, RMSD 0.27 Å
- 7UTC chain D against the predicted model P14941: TM-score 1.00, RMSD 0.27 Å
- 7UX4 chain C against the predicted model P14941: TM-score 1.00, RMSD 0.27 Å
- 7UX4 chain C against the predicted model P14941: TM-score 1.00, RMSD 0.27 Å
- 7UTC chain C against the predicted model P14941: TM-score 1.00, RMSD 0.30 Å
- 7UTC chain C against the predicted model P14941: TM-score 1.00, RMSD 0.30 Å
- 7UUT chain C against the predicted model P14941: TM-score 1.00, RMSD 0.30 Å
- 7UUT chain C against the predicted model P14941: TM-score 1.00, RMSD 0.30 Å
- 3FTN chain A against the predicted model P14941: TM-score 1.00, RMSD 0.30 Å
- 3FTN chain A against the predicted model P14941: TM-score 1.00, RMSD 0.30 Å
Elsewhere
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