MolNFT v1 · #63783 · protein
Crystal structure of tetr triple mutant (H64K, S135L, S138I)
3FK6 · Tetracycline repressor protein class B from transposon…: “Crystal structure of tetr triple mutant (H64K, S135L, S138I)”. X-ray diffraction, 6 pockets (best druggability 0.82). MolNFT v1 #63783 on GenesisL1: 3D structure, binding…
- PDB
- 3FK6
- Type
- protein
- Length
- 389 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tetracycline repressor protein class B from transposon TN10, tetracycline repressor…
- UniProt
- P04483, P0ACT4
- Pockets
- 6 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tetracycline repressor protein class B from transposon TN10, tetracycline repressor protein class D | protein | 195 | 75% helix, 0% strand | P04483, P0ACT4 |
| B | Tetracycline repressor protein class B from transposon TN10, tetracycline repressor protein class D | protein | 194 | 74% helix, 0% strand | P04483, P0ACT4 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 420 | 0.82 | 0.90 | 42 | empty |
| 2 | 467 | 0.81 | 0.88 | 50 | empty |
| 3 | 90 | 0.57 | 0.87 | 19 | empty |
| 4 | 141 | 0.49 | 0.79 | 21 | empty |
| 5 | 95 | 0.37 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 2858 Ų buried · 26 hydrogen bonds · protein-protein
Compared structures
- 3FK6 · Crystal structure of TetR triple mutant (H64K, S135L, S138I) · the same entry in another collection · chain A against A, TM-score 1.00
- P0ACT4 · AlphaFold monomer V2.0 prediction for tetracycline repressor protein class D (P0ACT4) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P04483 · AlphaFold monomer V2.0 prediction for tetracycline repressor protein class B from… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04483
- Every structure of UniProt P0ACT4
- Elsewhere: RCSB PDB 3FK6 · PDBe 3FK6 · UniProt P04483 · UniProt P0ACT4
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