MolNFT v1 · #63710 · protein
Structural basis of salmonella typhi type ivb pils and cystic fibrosis transmembrane conductance regulator (cftr) interaction
3FHV · Prepilin: “Structural basis of salmonella typhi type ivb pils and cystic fibrosis transmembrane conductance regulator…”. X-ray diffraction, 4 pockets (best druggability 0.43). MolNFT v1 #63710 on GenesisL1: 3D structure, binding…
- PDB
- 3FHV
- Type
- protein
- Length
- 310 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Prepilin; Cftr peptide
- UniProt
- Q8Z1L1
- Pockets
- 4 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Prepilin | protein | 150 | 35% helix, 28% strand | Q8Z1L1 |
| C | Cftr peptide | protein | 10 | 0% helix, 0% strand | — |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 86 | 0.43 | 0.79 | 22 | empty |
| 2 | 106 | 0.38 | 0.75 | 26 | empty |
| 3 | 64 | 0.33 | 0.77 | 23 | empty |
| 4 | 50 | 0.29 | 0.76 | 13 | empty |
Interfaces
3 interfaces between chains.
- A–B · 466 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 375 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 278 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 d-amino, 2 disulfide (D-amino acid, disulfide).
Compared structures
- 3FHV · Structural basis of Salmonella typhi type IVb PilS and cystic fibrosis transmembrane… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8Z1L1
- Elsewhere: RCSB PDB 3FHV · PDBe 3FHV · UniProt Q8Z1L1
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