Research workbench
Structural basis of salmonella typhi type ivb pils and cystic fibrosis transmembrane conductance regulator (cftr) interaction
Analyse Structural basis of salmonella typhi type ivb pils and cystic fibrosis… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3FHV
- Type
- protein
- Length
- 310 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Prepilin; Cftr peptide
- UniProt
- Q8Z1L1
- Pockets
- 4 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Prepilin | protein | 150 | 35% helix, 28% strand | Q8Z1L1 |
| C | Cftr peptide | protein | 10 | 0% helix, 0% strand | — |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 86 | 0.43 | 0.79 | 22 | empty |
| 2 | 106 | 0.38 | 0.75 | 26 | empty |
| 3 | 64 | 0.33 | 0.77 | 23 | empty |
| 4 | 50 | 0.29 | 0.76 | 13 | empty |
Interfaces
3 interfaces between chains.
- A–B · 466 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 375 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 278 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 d-amino, 2 disulfide (D-amino acid, disulfide).
Compared structures
- 3FHV · Structural basis of Salmonella typhi type IVb PilS and cystic fibrosis transmembrane… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8Z1L1
- Elsewhere: RCSB PDB 3FHV · PDBe 3FHV · UniProt Q8Z1L1
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