MolNFT v1 · #63655 · protein

Structure of the C-terminus of adseverin

3FG6: “Structure of the C-terminus of adseverin”. X-ray diffraction, 1 ligand (CA), 20 pockets (best druggability 0.85). MolNFT v1 #63655 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3FG6
Type: protein
Length: 2,375 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Adseverin
UniProt: Q9Y6U3
Ligands: CA
Pockets: 20 · best druggability 0.85

Structure

x-ray diffraction · 6 distinct chains · 23% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, G, B	Adseverin	protein	296	22% helix, 30% strand	Q9Y6U3
C	Adseverin	protein	303	23% helix, 30% strand	Q9Y6U3
E	Adseverin	protein	285	22% helix, 31% strand	Q9Y6U3
F	Adseverin	protein	300	25% helix, 29% strand	Q9Y6U3
H	Adseverin	protein	306	24% helix, 31% strand	Q9Y6U3
D	Adseverin	protein	293	23% helix, 33% strand	Q9Y6U3

Ligands and binding sites

CA · Calcium ion · metal · 23 copies · chains A, H, C, G, E, F, D, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	971	0.85	0.86	112	empty
2	615	0.79	0.85	77	CA
3	675	0.78	0.83	96	CA
4	624	0.77	0.83	88	empty
5	671	0.76	0.82	72	empty

Interfaces

14 interfaces between chains.

E–F · 1302 Å² buried · 14 hydrogen bonds · protein-protein
A–H · 526 Å² buried · 7 hydrogen bonds · protein-protein
G–B · 429 Å² buried · 3 hydrogen bonds · protein-protein
E–H · 404 Å² buried · 5 hydrogen bonds · protein-protein
H–B · 403 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

3FG6 · Structure of the C-terminus of Adseverin · the same entry in another collection · chain B against B, TM-score 1.00
Q9Y6U3 · AlphaFold monomer V2.0 prediction for adseverin (Q9Y6U3) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y6U3
Elsewhere: RCSB PDB 3FG6 · PDBe 3FG6 · UniProt Q9Y6U3

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.