MolNFT v1 · #63626 · protein
Crystal structure of a fast activating G protein mutant
3FFA · Guanine nucleotide-binding protein G(I), alpha-1 subunit: “Crystal structure of a fast activating G protein mutant”. X-ray diffraction, 3 ligands (GSP, MG, SO4), 2 pockets (best druggability 0.72). MolNFT v1 #63626 on GenesisL1: 3D…
- PDB
- 3FFA
- Type
- protein
- Length
- 316 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(I), alpha-1 subunit
- UniProt
- P10824
- Ligands
- GSP, MG, SO4
- Pockets
- 2 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(I), alpha-1 subunit | protein | 316 | 52% helix, 15% strand | P10824 |
Ligands and binding sites
- GSP · 5'-guanosine-diphosphate-monothiophosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 252 | 0.72 | 0.87 | 40 | GSP, MG |
| 2 | 290 | 0.62 | 0.80 | 37 | empty |
Compared structures
- 3FFA · Crystal Structure of a fast activating G protein mutant · the same entry in another collection · chain A against A, TM-score 1.00
- P10824 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10824
- Elsewhere: RCSB PDB 3FFA · PDBe 3FFA · UniProt P10824
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