MolNFT v1 · #63481 · protein
Crystal structure of the human brain alpha spectrin repeats 15 and 16. northeast structural genomics consortium target HR5563A.
3FB2 · Spectrin alpha chain, brain spectrin: “Crystal structure of the human brain alpha spectrin repeats 15 and 16. northeast structural genomics…”. X-ray diffraction, 2 pockets (best druggability 0.67). MolNFT v1 #63481 on GenesisL1: 3D…
- PDB
- 3FB2
- Type
- protein
- Length
- 390 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Spectrin alpha chain, brain spectrin
- UniProt
- Q13813
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 86% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Spectrin alpha chain, brain spectrin | protein | 188 | 86% helix, 0% strand | Q13813 |
| B | Spectrin alpha chain, brain spectrin | protein | 202 | 86% helix, 0% strand | Q13813 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 288 | 0.67 | 0.82 | 47 | empty |
| 2 | 119 | 0.63 | 0.87 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 1195 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 3FB2 · Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast… · the same entry in another collection · chain B against B, TM-score 1.00
- Q13813 · AlphaFold monomer V2.0 prediction for spectrin alpha chain, non- erythrocytic 1 (Q13813) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13813
- Elsewhere: RCSB PDB 3FB2 · PDBe 3FB2 · UniProt Q13813
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