Research workbench
Crystal structure of the human brain alpha spectrin repeats 15 and 16. northeast structural genomics consortium target HR5563A.
Analyse Crystal structure of the human brain alpha spectrin repeats 15 and 16.… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3FB2
- Type
- protein
- Length
- 390 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Spectrin alpha chain, brain spectrin
- UniProt
- Q13813
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 86% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Spectrin alpha chain, brain spectrin | protein | 188 | 86% helix, 0% strand | Q13813 |
| B | Spectrin alpha chain, brain spectrin | protein | 202 | 86% helix, 0% strand | Q13813 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 288 | 0.67 | 0.82 | 47 | empty |
| 2 | 119 | 0.63 | 0.87 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 1195 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 3FB2 · Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast… · the same entry in another collection · chain B against B, TM-score 1.00
- Q13813 · AlphaFold monomer V2.0 prediction for spectrin alpha chain, non- erythrocytic 1 (Q13813) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13813
- Elsewhere: RCSB PDB 3FB2 · PDBe 3FB2 · UniProt Q13813
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