MolNFT v1 · #63345 · protein
Crystal structure of pseudomonas aeruginosa mlic in complex with hen egg white lysozyme
3F6Z · Lysozyme C: “Crystal structure of pseudomonas aeruginosa mlic in complex with hen egg white lysozyme”. X-ray diffraction, 3 pockets (best druggability 0.66). MolNFT v1 #63345 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 3F6Z
- Type
- protein
- Length
- 444 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lysozyme C; Putative uncharacterized protein
- EC
- 3.2.1.17
- UniProt
- P00698, Q9I574
- Pockets
- 3 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Lysozyme C (EC 3.2.1.17) | protein | 129 | 44% helix, 12% strand | P00698 |
| B, D | Putative uncharacterized protein | protein | 93 | 0% helix, 68% strand | Q9I574 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 623 | 0.66 | 0.75 | 47 | empty |
| 2 | 87 | 0.42 | 0.79 | 17 | empty |
| 3 | 84 | 0.38 | 0.77 | 16 | empty |
Interfaces
5 interfaces between chains.
- B–D · 1280 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 985 Ų buried · 24 hydrogen bonds · protein-protein
- C–D · 979 Ų buried · 25 hydrogen bonds · protein-protein
- B–C · 123 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 120 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 3F6Z · Crystal structure of Pseudomonas aeruginosa MliC in complex with hen egg white lysozyme · the same entry in another collection · chain A against A, TM-score 1.00
- Q9I574 · AlphaFold monomer V2.0 prediction for membrane-bound lysozyme inhibitor of C-type… · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00698
- Every structure of UniProt Q9I574
- Elsewhere: RCSB PDB 3F6Z · PDBe 3F6Z · UniProt P00698 · UniProt Q9I574
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