MolNFT v1 · #63303 · protein
Crystal structure of putative short chain dehydrogenase from escherichia COLI CFT073
3F5Q: “Crystal structure of putative short chain dehydrogenase from escherichia COLI CFT073”. X-ray diffraction, 4 pockets (best druggability 0.59). MolNFT v1 #63303 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3F5Q
- Type
- protein
- Length
- 457 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dehydrogenase
- EC
- 1.-.-.-
- UniProt
- Q8FHV3
- Pockets
- 4 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dehydrogenase (EC 1.-.-.-) | protein | 228 | 46% helix, 15% strand | Q8FHV3 |
| B | Dehydrogenase (EC 1.-.-.-) | protein | 229 | 46% helix, 15% strand | Q8FHV3 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 334 | 0.59 | 0.77 | 39 | empty |
| 2 | 338 | 0.58 | 0.76 | 40 | empty |
| 3 | 167 | 0.45 | 0.74 | 23 | empty |
| 4 | 132 | 0.43 | 0.76 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 296 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3F5Q · CRYSTAL STRUCTURE OF putative short chain dehydrogenase from Escherichia coli CFT073 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8FHV3
- Elsewhere: RCSB PDB 3F5Q · PDBe 3F5Q · UniProt Q8FHV3
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