Crystal structure of toxoplasma gondii micronemal protein 1 bound to 3'SIALACNAC1-3

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 33% strand (DSSP).

Ligands and binding sites

• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar
• GAL · beta-D-galactopyranose · sugar · chains A
• SIA · N-acetyl-alpha-neuraminic acid · sugar · chains A
• CL · Chloride ion · ion · chains A
• ACT · Acetate ion · additive · 8 copies · chains A
• GOL · Glycerol · additive · 5 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 8 disulfide, 2 modified (disulfide, engineered).

Compared structures

• 3F5A · Crystal structure of Toxoplasma gondii micronemal protein 1 bound to 3'SiaLacNAc1-3 · the same entry in another collection · chain A against A, TM-score 1.00
• O00834 · AlphaFold monomer V2.0 prediction for micronemal protein 1 (O00834) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O00834
• Elsewhere: RCSB PDB 3F5A · PDBe 3F5A · UniProt O00834