MolNFT v1 · #63023 · protein
K314A mutant of human orotidyl-5'-monophosphate decarboxylase soaked with omp, decarboxylated to ump
3EWY · Orotidine-5'-phosphate decarboxylase: “K314A mutant of human orotidyl-5'-monophosphate decarboxylase soaked with omp, decarboxylated to ump”. X-ray diffraction, 1 ligand (U5P), 1 pocket (best druggability 0.56). MolNFT v1 #63023 on…
- PDB
- 3EWY
- Type
- protein
- Length
- 257 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Orotidine-5'-phosphate decarboxylase
- EC
- 4.1.1.23
- UniProt
- P11172
- Ligands
- U5P
- Pockets
- 1 · best druggability 0.56
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Orotidine-5'-phosphate decarboxylase (EC 4.1.1.23) | protein | 257 | 44% helix, 17% strand | P11172 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 246 | 0.56 | 0.78 | 37 | U5P |
Modifications
Observed in the structure: 1 modified (artifact).
Compared structures
- 3EWY · K314A mutant of human orotidyl-5'-monophosphate decarboxylase soaked with OMP… · the same entry in another collection · chain A against A, TM-score 1.00
- P11172 · AlphaFold monomer V2.0 prediction for uridine 5'-monophosphate synthase (P11172) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11172
- Elsewhere: RCSB PDB 3EWY · PDBe 3EWY · UniProt P11172
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